Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ

Targeting the PI3K isoform p110δ against B cell malignancies is at the mainstay of PI3K inhibitor (PI3Ki) development. Therefore, we generated isogenic cell lines, which express wild type or mutant p110δ, for assessing the potency, isoform-selectivity and molecular interactions of various PI3Ki chem...

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Detalles Bibliográficos
Autores principales: Hassenrück, Floyd, Farina-Morillas, Maria, Neumann, Lars, Landini, Francesco, Blakemore, Stuart James, Rabipour, Mina, Alvarez-Idaboy, Juan Raul, Pallasch, Christian P., Hallek, Michael, Rebollido-Rios, Rocio, Krause, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241892/
https://www.ncbi.nlm.nih.gov/pubmed/37277510
http://dx.doi.org/10.1038/s42003-023-04921-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241892/
https://www.ncbi.nlm.nih.gov/pubmed/37277510
http://dx.doi.org/10.1038/s42003-023-04921-z

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