Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway

Prostasin (PRSS8) is a serine protease that metabolizes and moderates the effect of specific substrates. Epidermal growth factor receptor (EGFR), which modulates insulin secretion and pancreatic β-cell proliferation, is regulated via proteolytic shedding by PRSS8. We first detected PRSS8 expression...

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Detalles Bibliográficos
Autores principales: Ishii, Toshihisa, Miyasato, Yoshikazu, Ichijo, Masashi, Uchimura, Kohei, Furuya, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241893/
https://www.ncbi.nlm.nih.gov/pubmed/37277555
http://dx.doi.org/10.1038/s41598-023-36326-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241893/
https://www.ncbi.nlm.nih.gov/pubmed/37277555
http://dx.doi.org/10.1038/s41598-023-36326-7

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