Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL(pro) and M(pro) proteases, and nsp14 guanine N7-methyltransferase

Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (M(pro), 3CL(pro)) and papain-like protease (PL(pro)) are responsible for viral polyprotein cleavage—a process crucial for viral survival and replication. Recently it was shown...

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Detalles Bibliográficos
Autores principales: Zmudzinski, Mikolaj, Rut, Wioletta, Olech, Kamila, Granda, Jarosław, Giurg, Mirosław, Burda-Grabowska, Małgorzata, Kaleta, Rafał, Zgarbova, Michala, Kasprzyk, Renata, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Kesik-Brodacka, Malgorzata, Olsen, Shaun K., Weber, Jan, Hilgenfeld, Rolf, Jemielity, Jacek, Drag, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242237/
https://www.ncbi.nlm.nih.gov/pubmed/37280236
http://dx.doi.org/10.1038/s41598-023-35907-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242237/
https://www.ncbi.nlm.nih.gov/pubmed/37280236
http://dx.doi.org/10.1038/s41598-023-35907-w

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