Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases

CRISPR-Cas9 introduces targeted DNA breaks that engage competing DNA repair pathways, producing a spectrum of imprecise insertion/deletion mutations (indels) and precise templated mutations (precise edits). The relative frequencies of these pathways are thought to primarily depend on genomic sequenc...

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Detalles Bibliográficos
Autores principales: Chauhan, Vikash P., Sharp, Phillip A., Langer, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242711/
https://www.ncbi.nlm.nih.gov/pubmed/36881621
http://dx.doi.org/10.1073/pnas.2300605120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242711/
https://www.ncbi.nlm.nih.gov/pubmed/36881621
http://dx.doi.org/10.1073/pnas.2300605120

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