Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer

BACKGROUND: Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to therapy. We studied the expression of glycogen synthase 1 (GYS1), the key regulator...

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Detalles Bibliográficos
Autores principales: de Heer, E. C., Zois, C. E., Bridges, E., van der Vegt, B., Sheldon, H., Veldman, W. A., Zwager, M. C., van der Sluis, T., Haider, S., Morita, T., Baba, O., Schröder, C. P., de Jong, S., Harris, A. L., Jalving, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242793/
https://www.ncbi.nlm.nih.gov/pubmed/37280675
http://dx.doi.org/10.1186/s13046-023-02715-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242793/
https://www.ncbi.nlm.nih.gov/pubmed/37280675
http://dx.doi.org/10.1186/s13046-023-02715-z

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