Affinity selection of double-click triazole libraries for rapid discovery of allosteric modulators for GLP-1 receptor

The recently developed double-click reaction sequence [G. Meng et al., Nature 574, 86–89 (2019)] is expected to vastly expand the number and diversity of synthetically accessible 1,2,3-triazole derivatives. However, it remains elusive how to rapidly navigate the extensive chemical space created by d...

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Detalles Bibliográficos
Autores principales: Xin, Ye, Liu, Shuo, Liu, Yan, Qian, Zhen, Liu, Hongyue, Zhang, Bingjie, Guo, Taijie, Thompson, Garth J., Stevens, Raymond C., Sharpless, K. Barry, Dong, Jiajia, Shui, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243133/
https://www.ncbi.nlm.nih.gov/pubmed/36893261
http://dx.doi.org/10.1073/pnas.2220767120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243133/
https://www.ncbi.nlm.nih.gov/pubmed/36893261
http://dx.doi.org/10.1073/pnas.2220767120

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