Highly regioselective and diastereoselective synthesis of novel pyrazinoindolones via a base-mediated Ugi-N-alkylation sequence

An efficient base-mediated/metal-free approach has been developed for the synthesis of 1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide derivatives via intramolecular indole N–H alkylation of novel bis-amide Ugi-adducts. In this protocol the Ugi reaction of (E)-cinnamaldehyde derivatives,...

Descripción completa

Detalles Bibliográficos
Autores principales: Tajik, Maryam, Shiri, Morteza, Hussain, Faiq H. S., Lotfi Nosood, Yazdanbakhsh, Baeiszadeh, Behnaz, Amini, Zahra, Bikas, Rahman, Pyra, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243185/
https://www.ncbi.nlm.nih.gov/pubmed/37288378
http://dx.doi.org/10.1039/d3ra02065g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243185/
https://www.ncbi.nlm.nih.gov/pubmed/37288378
http://dx.doi.org/10.1039/d3ra02065g

Ejemplares similares