HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation

PURPOSE: HSF4 mutations are responsible for congenital cataract formation. Dysfunction of HSF4 leads to defects in lens terminal differentiation. We aimed to study the mechanism of how HSF4 promotes organelle degradation during lens differentiation. METHODS: HSF4(del42) mutant mice that developed co...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Jiang, Ning, Du, Chunxiao, Guo, Hongzan, Meng, Ranqi, Hou, Xinyu, Liu, Mugen, Hu, Yanzhong, Cui, Xiukun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243497/
https://www.ncbi.nlm.nih.gov/pubmed/37266953
http://dx.doi.org/10.1167/iovs.64.7.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243497/
https://www.ncbi.nlm.nih.gov/pubmed/37266953
http://dx.doi.org/10.1167/iovs.64.7.5

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