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Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca(2+) Signalling

We recently reported that the ER stress kinase PERK regulates ER-mitochondria appositions and ER– plasma membrane (ER-PM) contact sites, independent of its canonical role in the unfolded protein response. PERK regulation of ER-PM contacts was revealed by a proximity biotinylation (BioID) approach an...

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Detalles Bibliográficos
Autores principales: Sassano, Maria Livia, Derua, Rita, Waelkens, Etienne, Agostinis, Patrizia, van Vliet, Alexander R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243573/
https://www.ncbi.nlm.nih.gov/pubmed/37366380
http://dx.doi.org/10.1177/25152564211052392