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Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction

Adipose tissue macrophages (ATMs) play an important role in obesity and inflammation, and they accumulate in adipose tissue (AT) with aging. Furthermore, increased ATM senescence has been shown in obesity-related AT remodeling and dysfunction. However, ATM senescence and its role are unclear in age-...

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Detalles Bibliográficos
Autores principales: Sawaki, Daigo, Zhang, Yanyan, Mohamadi, Amel, Pini, Maria, Mezdari, Zaineb, Lipskaia, Larissa, Naushad, Suzain, Lamendour, Lucille, Altintas, Dogus Murat, Breau, Marielle, Liang, Hao, Halfaoui, Maissa, Delmont, Thaïs, Surenaud, Mathieu, Rousseau, Déborah, Yoshimitsu, Takehiko, Louache, Fawzia, Adnot, Serge, Henegar, Corneliu, Gual, Philippe, Czibik, Gabor, Derumeaux, Geneviève
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243739/
https://www.ncbi.nlm.nih.gov/pubmed/37092554
http://dx.doi.org/10.1172/jci.insight.145811