Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K(+)CD8(+) T cells in primary Sjögren’s syndrome

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune inflammatory disease mainly defined by T cell–dominated destruction of exocrine glands. Currently, CD8(+) T cells are thought to be involved in the pathogenesis of pSS. However, the single-cell immune profiling of pSS and molecular signatures...

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Detalles Bibliográficos
Autores principales: Xu, Ting, Zhu, Hao-Xian, You, Xing, Ma, Jin-Fen, Li, Xin, Luo, Pan-Yue, Li, Yang, Lian, Zhe-Xiong, Gao, Cai-Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243796/
https://www.ncbi.nlm.nih.gov/pubmed/36881472
http://dx.doi.org/10.1172/jci.insight.167490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243796/
https://www.ncbi.nlm.nih.gov/pubmed/36881472
http://dx.doi.org/10.1172/jci.insight.167490

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