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Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K(+)CD8(+) T cells in primary Sjögren’s syndrome
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune inflammatory disease mainly defined by T cell–dominated destruction of exocrine glands. Currently, CD8(+) T cells are thought to be involved in the pathogenesis of pSS. However, the single-cell immune profiling of pSS and molecular signatures...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243796/ https://www.ncbi.nlm.nih.gov/pubmed/36881472 http://dx.doi.org/10.1172/jci.insight.167490 |