Myocardial fibrosis and calcification are attenuated by microRNA–129-5p targeting Asporin and Sox9 in cardiac fibroblasts

Myocardial fibrosis and calcification associate with adverse outcomes in nonischemic heart failure. Cardiac fibroblasts (CF) transition into myofibroblasts (MF) and osteogenic fibroblasts (OF) to promote myocardial fibrosis and calcification. However, common upstream mechanisms regulating both CF-to...

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Detalles Bibliográficos
Autores principales: Medzikovic, Lejla, Aryan, Laila, Ruffenach, Grégoire, Li, Min, Savalli, Nicoletta, Sun, Wasila, Sarji, Shervin, Hong, Jason, Sharma, Salil, Olcese, Riccardo, Fishbein, Gregory, Eghbali, Mansoureh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243800/
https://www.ncbi.nlm.nih.gov/pubmed/37154157
http://dx.doi.org/10.1172/jci.insight.168655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243800/
https://www.ncbi.nlm.nih.gov/pubmed/37154157
http://dx.doi.org/10.1172/jci.insight.168655

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