MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity

Makorin ring finger protein 3 (MKRN3) was identified as an inhibitor of puberty initiation with the report of loss-of-function mutations in association with central precocious puberty. Consistent with this inhibitory role, a prepubertal decrease in Mkrn3 expression was observed in the mouse hypothal...

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Detalles Bibliográficos
Autores principales: Naulé, Lydie, Mancini, Alessandra, Pereira, Sidney A., Gassaway, Brandon M., Lydeard, John R., Magnotto, John C., Kim, Han Kyeol, Liang, Joy, Matos, Cynara, Gygi, Steven P., Merkle, Florian T., Carroll, Rona S., Abreu, Ana Paula, Kaiser, Ursula B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243807/
https://www.ncbi.nlm.nih.gov/pubmed/37092553
http://dx.doi.org/10.1172/jci.insight.164178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243807/
https://www.ncbi.nlm.nih.gov/pubmed/37092553
http://dx.doi.org/10.1172/jci.insight.164178

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