Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis

Synovial fibroblasts (SFs) are key pathogenic drivers in rheumatoid arthritis (RA). Their in vivo activation by TNF is sufficient to orchestrate full arthritic pathogenesis in animal models, and TNF blockade proved efficacious for a high percentage of patients with RA albeit coinducing rare but seri...

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Detalles Bibliográficos
Autores principales: Papadopoulou, Dimitra, Roumelioti, Fani, Tzaferis, Christos, Chouvardas, Panagiotis, Pedersen, Anna-Kathrine, Charalampous, Filippos, Christodoulou-Vafeiadou, Eleni, Ntari, Lydia, Karagianni, Niki, Denis, Maria C., Olsen, Jesper V., Matralis, Alexios N., Kollias, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243819/
https://www.ncbi.nlm.nih.gov/pubmed/37014697
http://dx.doi.org/10.1172/jci.insight.165024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243819/
https://www.ncbi.nlm.nih.gov/pubmed/37014697
http://dx.doi.org/10.1172/jci.insight.165024

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