Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice

Gain-of-function mutations in the housekeeping gene GARS1, which lead to the expression of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory pathology characterizing Charcot-Marie-Tooth disease (CMT). Aberrant interactions between GlyRS mutants and different pro...

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Detalles Bibliográficos
Autores principales: Sleigh, James N., Villarroel-Campos, David, Surana, Sunaina, Wickenden, Tahmina, Tong, Yao, Simkin, Rebecca L., Vargas, Jose Norberto S., Rhymes, Elena R., Tosolini, Andrew P., West, Steven J., Zhang, Qian, Yang, Xiang-Lei, Schiavo, Giampietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243821/
https://www.ncbi.nlm.nih.gov/pubmed/36928301
http://dx.doi.org/10.1172/jci.insight.157191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243821/
https://www.ncbi.nlm.nih.gov/pubmed/36928301
http://dx.doi.org/10.1172/jci.insight.157191

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