The connection of α- and β-domains in mammalian metallothionein-2 differentiates Zn(II) binding affinities, affects folding, and determines zinc buffering properties

Mammalian metallothioneins (MTs) are small Cys-rich proteins involved in Zn(II) and Cu(I) homeostasis. They bind seven Zn(II) ions in two distinct β- and α-domains, forming Zn(3)Cys(9) and Zn(4)Cys(11) clusters, respectively. After six decades of research, their role in cellular buffering of Zn(II)...

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Detalles Bibliográficos
Autores principales: Singh, Avinash Kumar, Pomorski, Adam, Wu, Sylwia, Peris-Díaz, Manuel D, Czepczyńska-Krężel, Hanna, Krężel, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243857/
https://www.ncbi.nlm.nih.gov/pubmed/37147085
http://dx.doi.org/10.1093/mtomcs/mfad029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243857/
https://www.ncbi.nlm.nih.gov/pubmed/37147085
http://dx.doi.org/10.1093/mtomcs/mfad029

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