Population Pharmacokinetic−Pharmacodynamic Modeling of Carvedilol to Evaluate the Effect of Cytochrome P450 2D6 Genotype on the Heart Rate Reduction

BACKGROUND: Carvedilol is a beta-adrenergic receptor antagonist primarily metabolized by cytochromes P450 (CYP) 2D6. This study established a carvedilol population pharmacokinetic (PK)–pharmacodynamic (PD) model to describe the effects of CYP2D6 genetic polymorphisms on the inter-individual variabil...

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Detalles Bibliográficos
Autores principales: Hwang, Sejung, Lee, Soyoung, Yoon, Jangsoo, Chung, Jae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244018/
https://www.ncbi.nlm.nih.gov/pubmed/37272562
http://dx.doi.org/10.3346/jkms.2023.38.e173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244018/
https://www.ncbi.nlm.nih.gov/pubmed/37272562
http://dx.doi.org/10.3346/jkms.2023.38.e173

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