Ibrutinib sensitizes CLL cells to venetoclax by interrupting TLR9-induced CD40 upregulation and protein translation

Chronic lymphocytic leukemia (CLL) cells upregulate Bcl-2 proteins within the lymph node (LN) microenvironment. Signaling via B-cell receptor, Toll-like receptors and CD40 collectively reduce sensitivity to the BCL-2 inhibitor venetoclax. Time-limited treatment with venetoclax plus the BTK-inhibitor...

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Detalles Bibliográficos
Autores principales: Kielbassa, Karoline, Haselager, Marco V., Bax, Danique J. C., van Driel, Bianca F., Dubois, Julie, Levin, Mark-David, Kersting, Sabina, Svanberg, Rebecka, Niemann, Carsten U., Kater, Arnon P., Eldering, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244160/
https://www.ncbi.nlm.nih.gov/pubmed/37100883
http://dx.doi.org/10.1038/s41375-023-01898-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244160/
https://www.ncbi.nlm.nih.gov/pubmed/37100883
http://dx.doi.org/10.1038/s41375-023-01898-w

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