Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model

Polycythemia vera (PV) is a hematopoietic stem cell neoplasm driven by somatic mutations in JAK2, leading to increased red blood cell (RBC) production uncoupled from mechanisms that regulate physiological erythropoiesis. At steady-state, bone marrow macrophages promote erythroid maturation, whereas...

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Detalles Bibliográficos
Autores principales: Lysenko, Veronika, Schürch, Patrick M., Tuzlak, Selma, van Wijk, Nicole Wildner-Verhey, Kovtonyuk, Larisa V., Becher, Burkhard, Manz, Markus G., Kreutmair, Stefanie, Theocharides, Alexandre P. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244168/
https://www.ncbi.nlm.nih.gov/pubmed/37095207
http://dx.doi.org/10.1038/s41375-023-01903-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244168/
https://www.ncbi.nlm.nih.gov/pubmed/37095207
http://dx.doi.org/10.1038/s41375-023-01903-2

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