Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Early Alzheimer’s disease (AD) is associated with hippocampal hyperactivity and decreased sleep quality. Here we show that homeostatic mechanisms transiently counteract the increased excitatory drive to CA1 neurons in App(NL-G-F) mice, but that this mechanism fails in older mice. Spatial transcripto...

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Detalles Bibliográficos
Autores principales: Calafate, Sara, Özturan, Gökhan, Thrupp, Nicola, Vanderlinden, Jeroen, Santa-Marinha, Luísa, Morais-Ribeiro, Rafaela, Ruggiero, Antonella, Bozic, Ivan, Rusterholz, Thomas, Lorente-Echeverría, Blanca, Dias, Marcelo, Chen, Wei-Ting, Fiers, Mark, Lu, Ashley, Vlaeminck, Ine, Creemers, Eline, Craessaerts, Katleen, Vandenbempt, Joris, van Boekholdt, Luuk, Poovathingal, Suresh, Davie, Kristofer, Thal, Dietmar Rudolf, Wierda, Keimpe, Oliveira, Tiago Gil, Slutsky, Inna, Adamantidis, Antoine, De Strooper, Bart, de Wit, Joris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244178/
https://www.ncbi.nlm.nih.gov/pubmed/37188873
http://dx.doi.org/10.1038/s41593-023-01325-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244178/
https://www.ncbi.nlm.nih.gov/pubmed/37188873
http://dx.doi.org/10.1038/s41593-023-01325-4

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