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Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease
Early Alzheimer’s disease (AD) is associated with hippocampal hyperactivity and decreased sleep quality. Here we show that homeostatic mechanisms transiently counteract the increased excitatory drive to CA1 neurons in App(NL-G-F) mice, but that this mechanism fails in older mice. Spatial transcripto...
Autores principales: | Calafate, Sara, Özturan, Gökhan, Thrupp, Nicola, Vanderlinden, Jeroen, Santa-Marinha, Luísa, Morais-Ribeiro, Rafaela, Ruggiero, Antonella, Bozic, Ivan, Rusterholz, Thomas, Lorente-Echeverría, Blanca, Dias, Marcelo, Chen, Wei-Ting, Fiers, Mark, Lu, Ashley, Vlaeminck, Ine, Creemers, Eline, Craessaerts, Katleen, Vandenbempt, Joris, van Boekholdt, Luuk, Poovathingal, Suresh, Davie, Kristofer, Thal, Dietmar Rudolf, Wierda, Keimpe, Oliveira, Tiago Gil, Slutsky, Inna, Adamantidis, Antoine, De Strooper, Bart, de Wit, Joris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244178/ https://www.ncbi.nlm.nih.gov/pubmed/37188873 http://dx.doi.org/10.1038/s41593-023-01325-4 |
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