Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice

BACKGROUND: The primary pathophysiology of diabetic kidney disease (DKD) is tubulointerstitial fibrosis (TIF), and an essential contributing element is excessive extracellular matrix deposition. Irisin is a polypeptide formed by splitting fibronectin type III domain containing 5 (FNDC5), which parti...

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Detalles Bibliográficos
Autores principales: Yang, Zhaohua, Wei, Jinying, Wang, Yashu, Du, Yunxia, Song, Shan, Li, Jiawei, Su, Ziyuan, Shi, Yonghong, Wu, Haijiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244207/
https://www.ncbi.nlm.nih.gov/pubmed/37292142
http://dx.doi.org/10.2147/DMSO.S407734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244207/
https://www.ncbi.nlm.nih.gov/pubmed/37292142
http://dx.doi.org/10.2147/DMSO.S407734

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