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Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice

BACKGROUND: The primary pathophysiology of diabetic kidney disease (DKD) is tubulointerstitial fibrosis (TIF), and an essential contributing element is excessive extracellular matrix deposition. Irisin is a polypeptide formed by splitting fibronectin type III domain containing 5 (FNDC5), which parti...

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Detalles Bibliográficos
Autores principales:	Yang, Zhaohua, Wei, Jinying, Wang, Yashu, Du, Yunxia, Song, Shan, Li, Jiawei, Su, Ziyuan, Shi, Yonghong, Wu, Haijiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244207/ https://www.ncbi.nlm.nih.gov/pubmed/37292142 http://dx.doi.org/10.2147/DMSO.S407734

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