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Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3

The integrated stress response (ISR)-activated transcription factors ATF4 and CHOP/DDIT3 may regulate oligodendrocyte (OL) survival, tissue damage and functional impairment/recovery in white matter pathologies, including traumatic spinal cord injury (SCI). Accordingly, in OLs of OL-specific RiboTag...

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Detalles Bibliográficos
Autores principales: Gao, Yonglin, Wei, George Z., Forston, Michael D., Rood, Benjamin, Hodges, Emily R., Burke, Darlene, Andres, Kariena, Morehouse, Johnny, Armstrong, Christine, Glover, Charles, Slomnicki, Lukasz P., Ding, Jixiang, Chariker, Julia H., Rouchka, Eric C., Saraswat Ohri, Sujata, Whittemore, Scott R., Hetman, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244317/
https://www.ncbi.nlm.nih.gov/pubmed/37280306
http://dx.doi.org/10.1038/s41598-023-36258-2