Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts

Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Tumor progression depends on interactions of cancer cells with the tumor microenvironment. Here, we find increased copy number and mRNA expression of the catalytic subunit of telomerase, TERT, in tumors from NSCLC patients, contr...

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Detalles Bibliográficos
Autores principales: Piñeiro-Hermida, Sergio, Bosso, Giuseppe, Sánchez-Vázquez, Raúl, Martínez, Paula, Blasco, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244372/
https://www.ncbi.nlm.nih.gov/pubmed/37085672
http://dx.doi.org/10.1038/s41418-023-01149-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244372/
https://www.ncbi.nlm.nih.gov/pubmed/37085672
http://dx.doi.org/10.1038/s41418-023-01149-6

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