Site-directed mutagenesis of Mycobacterium tuberculosis and functional validation to investigate potential bedaquiline resistance-causing mutations

Molecular detection of bedaquiline resistant tuberculosis is challenging as only a small proportion of mutations in candidate bedaquiline resistance genes have been statistically associated with phenotypic resistance. We introduced two mutations, atpE Ile66Val and Rv0678 Thr33Ala, in the Mycobacteri...

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Detalles Bibliográficos
Autores principales: Otum, Christian C., Rivière, Emmanuel, Barnard, Monique, Loubser, Johannes, Williams, Monique J., Streicher, Elizabeth M., Van Rie, Annelies, Warren, Robin M., Klopper, Marisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244393/
https://www.ncbi.nlm.nih.gov/pubmed/37280265
http://dx.doi.org/10.1038/s41598-023-35563-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244393/
https://www.ncbi.nlm.nih.gov/pubmed/37280265
http://dx.doi.org/10.1038/s41598-023-35563-0

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