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Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain
There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants underlying the inherited movement disorder, Episodic Ataxia 1 (EA1). The Kwakwaka’wakw First Nations of the Pacific Northwest Coast used Fucus gardneri (bla...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244465/ https://www.ncbi.nlm.nih.gov/pubmed/37280215 http://dx.doi.org/10.1038/s41467-023-38834-6 |