Reversal of memory and autism-related phenotypes in Tsc2 ( +/− ) mice via inhibition of Nlgn1

Tuberous sclerosis complex (TSC) is a rare monogenic disorder co-diagnosed with high rates of autism and is caused by loss of function mutations in the TSC1 or TSC2 genes. A key pathway hyperactivated in TSC is the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), which regulates cap-dep...

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Detalles Bibliográficos
Autores principales: Chalkiadaki, Kleanthi, Statoulla, Elpida, Zafeiri, Maria, Haji, Nabila, Lacaille, Jean-Claude, Powell, Craig M., Jafarnejad, Seyed Mehdi, Khoutorsky, Arkady, Gkogkas, Christos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244498/
https://www.ncbi.nlm.nih.gov/pubmed/37293130
http://dx.doi.org/10.3389/fcell.2023.1205112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244498/
https://www.ncbi.nlm.nih.gov/pubmed/37293130
http://dx.doi.org/10.3389/fcell.2023.1205112

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