Tight hydrophobic core and flexible helices yield MscL with a high tension gating threshold and a membrane area mechanical strain buffer

The mechanosensitive (MS) channel of large conductance, MscL, is the high-tension threshold osmolyte release valve that limits turgor pressure in bacterial cells in the event of drastic hypoosmotic shock. Despite MscL from Mycobacterium tuberculosis (TbMscL) being the first structurally characterize...

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Detalles Bibliográficos
Autores principales: Sharma, Arjun, Anishkin, Andriy, Sukharev, Sergei, Vanegas, Juan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244533/
https://www.ncbi.nlm.nih.gov/pubmed/37292176
http://dx.doi.org/10.3389/fchem.2023.1159032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244533/
https://www.ncbi.nlm.nih.gov/pubmed/37292176
http://dx.doi.org/10.3389/fchem.2023.1159032

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