Loss or gain of function? Effects of ion channel mutations on neuronal firing depend on the neuron type

INTRODUCTION: Clinically relevant mutations to voltage-gated ion channels, called channelopathies, alter ion channel function, properties of ionic currents, and neuronal firing. The effects of ion channel mutations are routinely assessed and characterized as loss of function (LOF) or gain of functio...

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Detalles Bibliográficos
Autores principales: Koch, Nils A., Sonnenberg, Lukas, Hedrich, Ulrike B. S., Lauxmann, Stephan, Benda, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244640/
https://www.ncbi.nlm.nih.gov/pubmed/37292138
http://dx.doi.org/10.3389/fneur.2023.1194811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244640/
https://www.ncbi.nlm.nih.gov/pubmed/37292138
http://dx.doi.org/10.3389/fneur.2023.1194811

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