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Loss or gain of function? Effects of ion channel mutations on neuronal firing depend on the neuron type
INTRODUCTION: Clinically relevant mutations to voltage-gated ion channels, called channelopathies, alter ion channel function, properties of ionic currents, and neuronal firing. The effects of ion channel mutations are routinely assessed and characterized as loss of function (LOF) or gain of functio...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244640/ https://www.ncbi.nlm.nih.gov/pubmed/37292138 http://dx.doi.org/10.3389/fneur.2023.1194811 |