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Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis

Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-producing pancreatic beta cells are destroyed by CD8(+) cytotoxic T cells. The disease is challenging to study mechanistically in humans because it is not possible to biopsy the pancreatic islets and the disease is...

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Detalles Bibliográficos
Autores principales: De George, David J., Ge, Tingting, Krishnamurthy, Balasubramaniam, Kay, Thomas W. H., Thomas, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244651/
https://www.ncbi.nlm.nih.gov/pubmed/37293126
http://dx.doi.org/10.3389/fcell.2023.1205590