Virtual screening–based discovery of AI-2 quorum sensing inhibitors that interact with an allosteric hydrophobic site of LsrK and their functional evaluation

Introduction: Quorum sensing (QS) is a bacterial intracellular and intercellular communication system that regulates virulence factor production, biofilm formation, and antibiotic sensitivity. Quorum-sensing inhibitors (QSIs) are a novel class of antibiotics that can effectively combat antibiotic re...

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Detalles Bibliográficos
Autores principales: Shi, Qianqian, Wen, Huiqi, Xu, Yijie, Zhao, Xu, Zhang, Jing, Li, Ye, Meng, Qingbin, Yu, Fang, Xiao, Junhai, Li, Xingzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244669/
https://www.ncbi.nlm.nih.gov/pubmed/37292175
http://dx.doi.org/10.3389/fchem.2023.1185224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244669/
https://www.ncbi.nlm.nih.gov/pubmed/37292175
http://dx.doi.org/10.3389/fchem.2023.1185224

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