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Virtual screening–based discovery of AI-2 quorum sensing inhibitors that interact with an allosteric hydrophobic site of LsrK and their functional evaluation
Introduction: Quorum sensing (QS) is a bacterial intracellular and intercellular communication system that regulates virulence factor production, biofilm formation, and antibiotic sensitivity. Quorum-sensing inhibitors (QSIs) are a novel class of antibiotics that can effectively combat antibiotic re...
Autores principales: | Shi, Qianqian, Wen, Huiqi, Xu, Yijie, Zhao, Xu, Zhang, Jing, Li, Ye, Meng, Qingbin, Yu, Fang, Xiao, Junhai, Li, Xingzhou |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244669/ https://www.ncbi.nlm.nih.gov/pubmed/37292175 http://dx.doi.org/10.3389/fchem.2023.1185224 |
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