The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation

Protein lysine methyltransferases (PKMTs) play essential roles in gene expression regulation and cancer development. Somatic mutations in PKMTs are frequently observed in cancer cells. In biochemical experiments, we show here that the NSD1 mutations Y1971C, R2017Q, and R2017L observed mostly in soli...

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Detalles Bibliográficos
Autores principales: Khella, Mina S., Schnee, Philipp, Weirich, Sara, Bui, Tan, Bröhm, Alexander, Bashtrykov, Pavel, Pleiss, Jürgen, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244704/
https://www.ncbi.nlm.nih.gov/pubmed/37150325
http://dx.doi.org/10.1016/j.jbc.2023.104796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244704/
https://www.ncbi.nlm.nih.gov/pubmed/37150325
http://dx.doi.org/10.1016/j.jbc.2023.104796

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