Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers

The combination of inexpensive Fe(ii) acetate with low molecular weight aliphatic carboxamides in situ generates an effective catalyst system for the ring opening polymerisation of lactones. PLLAs were produced in melt conditions with molar masses of up to 15 kg mol(−1), narrow dispersity (Đ = 1.03)...

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Autores principales: Kirchhecker, Sarah, Nguyen, Ngoc, Reichert, Stefan, Lützow, Karola, Eselem Bungu, Paul S., Jacobi von Wangelin, Axel, Sandl, Sebastian, Neffe, Axel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244980/
https://www.ncbi.nlm.nih.gov/pubmed/37293470
http://dx.doi.org/10.1039/d3ra03112h
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author Kirchhecker, Sarah
Nguyen, Ngoc
Reichert, Stefan
Lützow, Karola
Eselem Bungu, Paul S.
Jacobi von Wangelin, Axel
Sandl, Sebastian
Neffe, Axel T.
author_facet Kirchhecker, Sarah
Nguyen, Ngoc
Reichert, Stefan
Lützow, Karola
Eselem Bungu, Paul S.
Jacobi von Wangelin, Axel
Sandl, Sebastian
Neffe, Axel T.
author_sort Kirchhecker, Sarah
collection PubMed
description The combination of inexpensive Fe(ii) acetate with low molecular weight aliphatic carboxamides in situ generates an effective catalyst system for the ring opening polymerisation of lactones. PLLAs were produced in melt conditions with molar masses of up to 15 kg mol(−1), narrow dispersity (Đ = 1.03), and without racemisation. The catalytic system was investigated in detail with regard to Fe(ii) source, and steric and electronic effects of the amide's substituents. Furthermore, the synthesis of PLLA-PCL block copolymers of very low randomness was achieved. This commercially available, inexpensive, modular, and user-friendly catalyst mixture may be suitable for polymers with biomedical applications.
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spelling pubmed-102449802023-06-08 Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers Kirchhecker, Sarah Nguyen, Ngoc Reichert, Stefan Lützow, Karola Eselem Bungu, Paul S. Jacobi von Wangelin, Axel Sandl, Sebastian Neffe, Axel T. RSC Adv Chemistry The combination of inexpensive Fe(ii) acetate with low molecular weight aliphatic carboxamides in situ generates an effective catalyst system for the ring opening polymerisation of lactones. PLLAs were produced in melt conditions with molar masses of up to 15 kg mol(−1), narrow dispersity (Đ = 1.03), and without racemisation. The catalytic system was investigated in detail with regard to Fe(ii) source, and steric and electronic effects of the amide's substituents. Furthermore, the synthesis of PLLA-PCL block copolymers of very low randomness was achieved. This commercially available, inexpensive, modular, and user-friendly catalyst mixture may be suitable for polymers with biomedical applications. The Royal Society of Chemistry 2023-06-07 /pmc/articles/PMC10244980/ /pubmed/37293470 http://dx.doi.org/10.1039/d3ra03112h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Kirchhecker, Sarah
Nguyen, Ngoc
Reichert, Stefan
Lützow, Karola
Eselem Bungu, Paul S.
Jacobi von Wangelin, Axel
Sandl, Sebastian
Neffe, Axel T.
Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers
title Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers
title_full Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers
title_fullStr Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers
title_full_unstemmed Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers
title_short Iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of PLLA and PLLA-PCL block copolymers
title_sort iron(ii) carboxylates and simple carboxamides: an inexpensive and modular catalyst system for the synthesis of plla and plla-pcl block copolymers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244980/
https://www.ncbi.nlm.nih.gov/pubmed/37293470
http://dx.doi.org/10.1039/d3ra03112h
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