In-silico analysis of TCGA data showing multiple POLE-like favourable subgroups overlapping with TP53 mutated endometrial cancer: Implications for clinical practice in low and middle-income countries

INTRODUCTION: The Cancer Genome Atlas cohort of endometrial carcinoma (TCGA-UCEC) includes almost 40% TP53-mutants encompassing missense and truncated variants. TCGA revealed ‘POLE’, characterized by POLE gene bearing exonuclease domain mutation (EDM), as the prognostically best molecular profile. T...

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Detalles Bibliográficos
Autores principales: Das Ghosh, Damayanti, Roy Chowdhury, Rahul, Dutta, Rajeswari, Mukhopadhyay, Indranil, Mukhopadhyay, Asima, Roychoudhury, Susanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Special Section on Global Gynecologic Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245003/
https://www.ncbi.nlm.nih.gov/pubmed/37293351
http://dx.doi.org/10.1016/j.gore.2023.101209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245003/
https://www.ncbi.nlm.nih.gov/pubmed/37293351
http://dx.doi.org/10.1016/j.gore.2023.101209

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