In-silico analysis of TCGA data showing multiple POLE-like favourable subgroups overlapping with TP53 mutated endometrial cancer: Implications for clinical practice in low and middle-income countries

INTRODUCTION: The Cancer Genome Atlas cohort of endometrial carcinoma (TCGA-UCEC) includes almost 40% TP53-mutants encompassing missense and truncated variants. TCGA revealed ‘POLE’, characterized by POLE gene bearing exonuclease domain mutation (EDM), as the prognostically best molecular profile. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Das Ghosh, Damayanti, Roy Chowdhury, Rahul, Dutta, Rajeswari, Mukhopadhyay, Indranil, Mukhopadhyay, Asima, Roychoudhury, Susanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Special Section on Global Gynecologic Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245003/
https://www.ncbi.nlm.nih.gov/pubmed/37293351
http://dx.doi.org/10.1016/j.gore.2023.101209

Ejemplares similares

Ejemplares similares