Prediction of Compound Plasma Concentration–Time Profiles in Mice Using Random Forest

[Image: see text] Pharmacokinetic (PK) parameters such as clearance (CL) and volume of distribution (Vd) have been the subject of previous in silico predictive models. However, having information of the concentration over time profile explicitly can provide additional value like time above MIC or AU...

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Detalles Bibliográficos
Autores principales: Handa, Koichi, Wright, Peter, Yoshimura, Saki, Kageyama, Michiharu, Iijima, Takeshi, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245373/
https://www.ncbi.nlm.nih.gov/pubmed/37096989
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245373/
https://www.ncbi.nlm.nih.gov/pubmed/37096989
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00071

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