RAFT Polymer–Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo

[Image: see text] Covalent conjugation of a biologically stable polymer to a therapeutic protein, e.g., an antibody, holds many benefits such as prolonged plasma exposure of the protein and improved tumor uptake. Generation of defined conjugates is advantageous in many applications, and a range of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ardana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J., Williams, Charlotte C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245379/
https://www.ncbi.nlm.nih.gov/pubmed/37218930
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245379/
https://www.ncbi.nlm.nih.gov/pubmed/37218930
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00085

Ejemplares similares