Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

BACKGROUND: Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor for late-onset Alzheimer’s Disease (AD). Although ApoE4 differs from its non-pathological ApoE3 isoform only by the C112R mutation, the molecular mechanism of its proteinopathy is unknown. METHODS: Here, we reveal the...

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Detalles Bibliográficos
Autores principales: Nemergut, Michal, Marques, Sérgio M., Uhrik, Lukas, Vanova, Tereza, Nezvedova, Marketa, Gadara, Darshak Chandulal, Jha, Durga, Tulis, Jan, Novakova, Veronika, Planas-Iglesias, Joan, Kunka, Antonin, Legrand, Anthony, Hribkova, Hana, Pospisilova, Veronika, Sedmik, Jiri, Raska, Jan, Prokop, Zbynek, Damborsky, Jiri, Bohaciakova, Dasa, Spacil, Zdenek, Hernychova, Lenka, Bednar, David, Marek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245438/
https://www.ncbi.nlm.nih.gov/pubmed/37280636
http://dx.doi.org/10.1186/s13024-023-00620-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245438/
https://www.ncbi.nlm.nih.gov/pubmed/37280636
http://dx.doi.org/10.1186/s13024-023-00620-9

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