Cargando…

Nebulised mesenchymal stem cell derived extracellular vesicles ameliorate E. coli induced pneumonia in a rodent model

BACKGROUND: Mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) have been proposed as an alternative to cell therapy, creating new possible delivery modalities such as nebulisation. We wished to investigate the therapeutic potential of directly nebulised MSC-EVs in the mitigation of Esc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonzalez, Hector, McCarthy, Sean, Masterson, Claire, Byrnes, Declan, Sallent, Ignacio, Horan, Emma, Elliman, Stephen J., Vella, Gabriele, Prina-Mello, Adriele, Silva, Johnatas D., Krasnodembskaya, Anna D., MacLoughlin, Ronan, Laffey, John G., O’Toole, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245544/ https://www.ncbi.nlm.nih.gov/pubmed/37280647 http://dx.doi.org/10.1186/s13287-023-03385-6

Ejemplares similares

Nebulized mesenchymal stem cell derived conditioned medium ameliorates Escherichia coli induced pneumonia in a rat model
por: González, Héctor E., et al.
Publicado: (2023)

Aerosolized Pulmonary Delivery of mRNA Constructs Attenuates Severity of Escherichia coli Pneumonia in the Rat
por: McCarthy, Sean D., et al.
Publicado: (2023)

Investigation of the Quantity of Exhaled Aerosols Released into the Environment during Nebulisation
por: McGrath, James A., et al.
Publicado: (2019)

Multiple Dosing and Preactivation of Mesenchymal Stromal Cells Enhance Efficacy in Established Pneumonia Induced by Antimicrobial-Resistant Klebsiella pneumoniae in Rodents
por: Byrnes, Declan, et al.
Publicado: (2023)

Delayed MSC therapy enhances resolution of organized pneumonia induced by antibiotic resistant Klebsiella pneumoniae infection
por: Byrnes, Declan, et al.
Publicado: (2023)

Enhancement strategies for mesenchymal stem cells and related therapies
por: Alagesan, Senthilkumar, et al.
Publicado: (2022)

Vibrating Mesh Nebulisation of Pro-Antimicrobial Peptides for Use in Cystic Fibrosis
por: Forde, Éanna, et al.
Publicado: (2019)

Hypercapnia in the critically ill: insights from the bench to the bedside
por: Masterson, Claire, et al.
Publicado: (2021)

Differential Effects of Cytokine Versus Hypoxic Preconditioning of Human Mesenchymal Stromal Cells in Pulmonary Sepsis Induced by Antimicrobial-Resistant Klebsiella pneumoniae
por: Byrnes, Declan, et al.
Publicado: (2023)

Nebuliser Type Influences Both Patient-Derived Bioaerosol Emissions and Ventilation Parameters during Mechanical Ventilation
por: Joyce, Mary, et al.
Publicado: (2021)

Nebulised lipid–polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells
por: Vencken, Sebastian, et al.
Publicado: (2019)

Umbilical cord-derived CD362(+) mesenchymal stromal cells for E. coli pneumonia: impact of dose regimen, passage, cryopreservation, and antibiotic therapy
por: Horie, Shahd, et al.
Publicado: (2020)

Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM-induced liver toxicity
por: Tutty, Melissa Anne, et al.
Publicado: (2022)

Inhaled CO(2) to Reduce Lung Ischemia and Reperfusion Injuries: Moving toward Clinical Translation?
por: Masterson, Claire H., et al.
Publicado: (2021)

Umbilical Cord-Derived CD362(+) Mesenchymal Stromal Cells Attenuate Polymicrobial Sepsis Induced by Caecal Ligation and Puncture
por: Gonzalez, Hector, et al.
Publicado: (2020)

Nanotechnology in pulmonary medicine
por: Doroudian, Mohammad, et al.
Publicado: (2021)

Investigation of Fugitive Aerosols Released into the Environment during High-Flow Therapy
por: McGrath, James A., et al.
Publicado: (2019)

Randomised controlled trial of nebulised gentamicin in children with bronchiectasis
por: Twiss, Jacob, et al.
Publicado: (2022)

Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay
por: Tutty, Melissa Anne, et al.
Publicado: (2022)

Correction: Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay
por: Tutty, Melissa Anne, et al.
Publicado: (2022)

Advancing mesenchymal stem cell therapy for asthma towards clinical translation
por: MacLoughlin, Ronan
Publicado: (2022)

Preclinical Development of Orally Inhaled Drugs (OIDs)—Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?
por: Movia, Dania, et al.
Publicado: (2020)

Zanamivir should be inhaled, not nebulised
por: Eagel, Barry A
Publicado: (2010)

Double Nebulisation for Airway Anaesthesia
por: Chugh, Vanya, et al.
Publicado: (2020)

Preparation from a revisited wet chemical route of phase-pure, monocrystalline and SHG-efficient BiFeO(3) nanoparticles for harmonic bio-imaging
por: Clarke, Gareth, et al.
Publicado: (2018)

Author Correction: Preparation from a revisited wet chemical route of phase-pure, monocrystalline and SHG-efficient BiFeO(3) nanoparticles for harmonic bio-imaging
por: Clarke, Gareth, et al.
Publicado: (2019)

Mesenchymal stromal cells are more effective than the MSC secretome in diminishing injury and enhancing recovery following ventilator-induced lung injury
por: Hayes, Mairead, et al.
Publicado: (2015)

Defining a Regulatory Strategy for ATMP/Aerosol Delivery Device Combinations in the Treatment of Respiratory Disease
por: Woods, Niamh, et al.
Publicado: (2020)

State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery
por: Brave, Hosanna, et al.
Publicado: (2020)

Hypercapnic acidosis attenuates pulmonary epithelial stretch-induced injury via inhibition of the canonical NF-κB pathway
por: Horie, Shahd, et al.
Publicado: (2016)

ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance
por: Movia, Dania, et al.
Publicado: (2019)

The effect of UV-protected ethylene vinyl acetate (EVA) bags on the physicochemical stability of pediatric parenteral nutrition admixtures
por: Watrobska-Swietlikowska, Dorota, et al.
Publicado: (2019)

In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective
por: Movia, Dania, et al.
Publicado: (2020)

Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials
por: Tutty, Melissa Anne, et al.
Publicado: (2022)

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence
por: van Haren, Frank M. P., et al.
Publicado: (2020)

The mesenchymal stromal cell magic bullet finds yet another target
por: Masterson, Claire, et al.
Publicado: (2014)

Internalization of ferromagnetic nanowires by different living cells
por: Prina-Mello, Adriele, et al.
Publicado: (2006)

Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs
por: Movia, Dania, et al.
Publicado: (2018)

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
por: Hannon, Gary, et al.
Publicado: (2020)

Editorial: Use of 3D Models in Drug Development and Precision Medicine - Advances and Outlook
por: Prina-Mello, Adriele, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_njfhtfulqvn3k5a21d0c34lcqe