Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification

Mixed phenotype acute leukemia (MPAL) is a leukemia whose biologic drivers are poorly understood, therapeutic strategy remains unclear, and prognosis is poor. We performed multiomic single cell (SC) profiling of 14 newly diagnosed adult MPAL patients to characterize the immunophenotypic, genetic, an...

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Detalles Bibliográficos
Autores principales: Peretz, Cheryl A. C., Kennedy, Vanessa E., Walia, Anushka, Delley, Cyrille L., Koh, Andrew, Tran, Elaine, Clark, Iain C., Hayford, Corey E., D’Amato, Chris, Xue, Yi, Fontanez, Kristina M., Roy, Ritu, Logan, Aaron C., Perl, Alexander E., Abate, Adam, Olshen, Adam, Smith, Catherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245585/
https://www.ncbi.nlm.nih.gov/pubmed/37292835
http://dx.doi.org/10.1101/2023.05.15.540305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245585/
https://www.ncbi.nlm.nih.gov/pubmed/37292835
http://dx.doi.org/10.1101/2023.05.15.540305

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