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Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification
Mixed phenotype acute leukemia (MPAL) is a leukemia whose biologic drivers are poorly understood, therapeutic strategy remains unclear, and prognosis is poor. We performed multiomic single cell (SC) profiling of 14 newly diagnosed adult MPAL patients to characterize the immunophenotypic, genetic, an...
Autores principales: | Peretz, Cheryl A. C., Kennedy, Vanessa E., Walia, Anushka, Delley, Cyrille L., Koh, Andrew, Tran, Elaine, Clark, Iain C., Hayford, Corey E., D’Amato, Chris, Xue, Yi, Fontanez, Kristina M., Roy, Ritu, Logan, Aaron C., Perl, Alexander E., Abate, Adam, Olshen, Adam, Smith, Catherine C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245585/ https://www.ncbi.nlm.nih.gov/pubmed/37292835 http://dx.doi.org/10.1101/2023.05.15.540305 |
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