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Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly

Centromeres direct genetic inheritance but are not themselves genetically encoded. Instead, centromeres are defined epigenetically by the presence of a histone H3 variant, CENP-A(1). In cultured somatic cells, an established paradigm of cell cycle-coupled propagation maintains centromere identity: C...

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Detalles Bibliográficos
Autores principales: Das, Arunika, Boese, Katelyn G., Tachibana, Kikue, Baek, Sung Hee, Lampson, Michael A., Black, Ben E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245701/
https://www.ncbi.nlm.nih.gov/pubmed/37292821
http://dx.doi.org/10.1101/2023.05.18.541332