The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

p97/VCP is an essential cytosolic AAA+ ATPase hexamer that extracts and unfolds substrate polypeptides during protein homeostasis and degradation. Distinct sets of p97 adapters guide cellular functions but their roles in direct control of the hexamer are unclear. The UBXD1 adapter localizes with p97...

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Detalles Bibliográficos
Autores principales: Braxton, Julian R., Altobelli, Chad R., Tucker, Maxwell R., Tse, Eric, Thwin, Aye C., Arkin, Michelle R., Southworth, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245715/
https://www.ncbi.nlm.nih.gov/pubmed/37292947
http://dx.doi.org/10.1101/2023.05.15.540864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245715/
https://www.ncbi.nlm.nih.gov/pubmed/37292947
http://dx.doi.org/10.1101/2023.05.15.540864

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