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Predicting structures of large protein assemblies using combinatorial assembly algorithm and AlphaFold2

Deep learning models, such as AlphaFold2 and RosettaFold, enable high-accuracy protein structure prediction. However, large protein complexes are still challenging to predict due to their size and the complexity of interactions between multiple subunits. Here we present CombFold, a combinatorial and...

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Detalles Bibliográficos
Autores principales: Shor, Ben, Schneidman-Duhovny, Dina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245790/
https://www.ncbi.nlm.nih.gov/pubmed/37293053
http://dx.doi.org/10.1101/2023.05.16.541003