Rescue of proteotoxic stress and neurodegeneration by the Zn(2+) transporter ZIP7

Proteotoxic stress drives numerous degenerative diseases. In response to misfolded proteins, cells adapt by activating the unfolded protein response (UPR), including endoplasmic reticulum-associated protein degradation (ERAD). However persistent stress triggers apoptosis. Enhancing ERAD is a promisi...

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Detalles Bibliográficos
Autores principales: Guo, Xiaoran, Mutch, Morgan, Torres, Alba Yurani, Nano, Maddalena, McDonald, Drew, Chen, Zijing, Montell, Craig, Dai, Wei, Montell, Denise J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245811/
https://www.ncbi.nlm.nih.gov/pubmed/37292980
http://dx.doi.org/10.1101/2023.05.22.541645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245811/
https://www.ncbi.nlm.nih.gov/pubmed/37292980
http://dx.doi.org/10.1101/2023.05.22.541645

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