Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

Eukaryotic translation initiation factor 4E (eIF4E) is an RNA-binding protein that binds to the m(7)GpppX-cap at the 5′ terminus of coding mRNAs to initiate cap-dependent translation. While all cells require cap-dependent translation, cancer cells become addicted to enhanced translational capacity,...

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Detalles Bibliográficos
Autores principales: Cárdenas, Emilio L., O’Rourke, Rachel L., Menon, Arya, Meagher, Jennifer, Stuckey, Jeanne, Garner, Amanda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245873/
https://www.ncbi.nlm.nih.gov/pubmed/37292917
http://dx.doi.org/10.1101/2023.05.23.541912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245873/
https://www.ncbi.nlm.nih.gov/pubmed/37292917
http://dx.doi.org/10.1101/2023.05.23.541912

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